Abstract:
Intrudaction: ABCG1 is the first member of the ABCG subfamily. The protein is expressed in many cell types and in numerous tissues including the kidney, lung, liver, and intestine. The aim of this study was to determine the small intestine and kidney ABCG1 relative gene expression in response to treadmill-running training in female rats.Material and Methods: Twenty Wistar rats (6-8 weeks old and 125-135 g weight) were used. Animals were randomly assigned into saline-control (SC), saline-training (ST), and Baneh-control (BC), and Baneh-training (BT). Training groups were given exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/dayand5 days/week for eight weeks. Subjects were fed orally, with Baneh extraction and saline for four weeks. ABCG1 relative gene expression was detected by Real-time PCR method.Results: results demonstrated that Baneh extraction significantly reduces ABCG1relative gene expression in small intestine (P < 0.02).Discussion and Conclusion: exercise training increases ABCG1relativegeneexpressionin small intestine; therefore exercise training may adjust the reduction in Baneh exercise group.
Machine summary:
"The aim of this study was to determine the small intestine and kidney ABCG1 relative gene expression in response to treadmill-running training in female rats.
Key Words: ABCG1, female rats, Treadmill exercise, ABC transporters, Pistachio atlantica Introduction Cholesterol and phospholipids are essential to the body, but toomuchof cholesterol or lipids are toxic and a risk factor for arteriosclerosis.
They reported that ABCA1 gene expression increases in rats’ liver and that the plasma levels of high density lipoprotein- cholesterol (HDL-C), Pre-β HDL and lecithin cholesterol acyltransferase (LCAT), significantly increased [13].
Khabazianet al showed that 12 weeks of aerobic exercise, increased mRNA expressions of ABCA1 gene expression in rat's small intestine[14].
Results ABCG1 relative gene expression in small intestine and kidney weredetermined in female rats.
Discussion and Conclusion To our knowledge, this is the first report to demonstrate alterations of female rat small intestine and kidney ABCG1relative gene expression in response to a treadmill running and Baneh crud extraction regime.
Anotherfinding was a lower relative gene expression ofABCG1 in Baneh-treated small intestine and kidney of rats when compared with saline-treated animals.
Khabazian et al showed that 12 weeks of aerobic exercise (intensity: 25 m/min, duration: 90 min/session and five days a week, 60 minutes a day, five days a week), increase mRNA expressions of rat΄s small intestinal ABCA1 gene expression [14].
In conclusion, the present study showed a significantlyhigher relative expression of ABCG1 mRNA in small intestine following treadmill running program in female rats.
Our results showed that Pistachiaatlantica (Baneh) mayreduce ABCG1 relative gene expression in small intestine, and kidney tissuedue to its essential fatty acids."