Abstract:
<em>Introduction:</em> Different kinds of chronic stress can induce various effects on body systems including the brain. One of the factors related to brain function is brain derived neurotropic factor (BDNF). So, the purpose of the present study was to evaluate the influence of physical stress as aerobic exercise/training and psychological stress on brain derived neurotropic factor (BDNF) in Wistar rats.<br /> <em>Material & Methods:</em> The study was semi experimental. 90 healthy male Wistar rats (weight 200±40 gr) were randomly divided in to 6 groups of Exercise (EX), Emotional stress (ES), Physical stress (PS), exercise combined with emotional (EXES), exercise combined with physical stress (EXPS) and control. Wistar rats were exposed to programs included one session (acute) and two weeks (chronic) aerobic training on treadmill with or without emotional and physical stress. Blood samples, for BDNF measurement, were taken 12 hours following the last session of treatment. Statistical tests of analysis of variance and follow up Bonferroni test were used for data analysis.<br /> <em>Results:</em> After one session of the experiment, BDNF increased significantly in the EX group compared to other groups (p<0.05). After two weeks of training, BDNF significantly decreased in the ES groups compared to other groups, while BDNF increased in EXES compared to ES (P<0.05) group. One session of EX increased BDNF compared to non-EX groups, but following two weeks, chronic ES per se reduced BDNF compared to non-ES groups. But when ES combined with EX caused increasing of BDNF.<br /> <em>Conclusions:</em> Present findings suggest that EX can probably prevent decreasing effect of ES on BDNF. However, future research should clarify the source of BDNF changes.
Machine summary:
The effects of chronic and acute physical and psychological Stress on Brain-Derived Neurotrophic Factor in Rats Sheida Ghanbari Ghooshchi1 and Maryam Koushkie Jahromi2* Received: 11 March 2018/ Accepted: 28 April 2018 (1) Department of Sport Sciences, School of Education & Psychology, Shiraz University, Iran.
So, the purpose of the present study was to evaluate the influence of physical stress as aerobic exercise/training and psychological stress on brain derived neurotropic factor (BDNF) in Wistar rats.
Wistar rats were exposed to programs included one session (acute) and two weeks (chronic) aerobic training on treadmill with or without emotional and physical stress.
Although, the association between EX, physical activity and mental health (13) and cognitive impairments (14) have been proved by many studies, but sport participation may impose somatic, social and mental stress (15).
Therefore, considering discrepancies in findings about influence of EX and ES on BDNF, we compared and studied the acute and chronic influence of combined and separate exercise, physical and emotional stress on serum BDNF in rats.
The significant level was set as P Results The BDNF descriptions (mean, SD, maximum and minimum) after the first session (acute response) and after 2 weeks (chronic) are presented in tables 1 and 2.
One way ANOVA test indicated a significant difference between study groups in BDNF following the one session of EX (F=4.
So, evaluating the influence of different acute and chronic stresses, separately or in combination, on physiological responses, including BDNF is important which was studied in the present research.
Different Circulating Brain-Derived Neurotrophic Factor responses to acute exercise between physically active and sedentary subjects.