Abstract:
<em>Introduction:</em> Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system. The aim of present study was to investigate the effect of eight weeks resistance training on interlukin-17 (IL-17) in women with MS.<br /> <em>Material & Methods:</em> Twenty seven women with MS disease in a range of 18-48 year of old and EDSS lower than 4.5 participated in this study as the subject. Subjects were divided into control group (n=13) or training group (n=14) randomly. The training group performed progressive resistance training program, 3 days a week for 8 weeks, whereas control group continued their usual routine activities. Serum level of IL-17 was measured by ELISA kits before and after training.<br /> <em>Results:</em> The disability score and IL-17 were significantly decreased from 1.8 to 1.3 and from 716.3 to 601.3 pg/ml respectively in test MS subjects after 8 weeks resistance training.<br /> <em>Conclusions:</em> In summary, the results suggest that resistance training has useful anti-inflammatory effects by decrease in serum IL-17 production in women with MS.
Machine summary:
Eight weeks resistance training reduces interlukin-17 in women with multiple sclerosis Amir Rahimi* Received: 28 October 2018 / Accepted: 29 December 2018 (*) MS in Exercise Physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.
The aim of present study was to investigate the effect of eight weeks resistance training on interlukin-17 (IL-17) in women with MS.
Conclusions: In summary, the results suggest that resistance training has useful anti-inflammatory effects by decrease in serum IL-17 production in women with MS.
Keywords: Multiple sclerosis, Resistance training, Inflammation, Cytokines 1.
The anti-inflammatory effect of exercise training in chronic illnesses is mediated by decreased pro-inflammatory cytokine IL-6, IL-8, TNF-α, and IFN-γ (20,21) and an increase in anti-inflammatory IL-10 concentration (20-22).
The aim of present study was to investigate the effect of eight weeks resistance training on IL-17 in women with MS.
Disability status tended to decrease in all subjects following the exercise program suggesting an improvement in their disability after 8 weeks of resistance training (from EDSS 1.
The results of present study indicated that IL-17 level was decreased in the training group compare to the control group (P IFN-γ level and the inhibitory effect of cytokines on the development of Th17.
Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis.
Resistance training improves muscle strength and functional capacity in multiple sclerosis.
Resistance training improves strength and functional capacity in persons with multiple sclerosis.
Effects of eight-week resistance training program in men with multiple sclerosis.