چکیده:
Aim: Irisin is a recently identified exercise-induced hormone that increases energy expenditure. The effect of chronic aerobic training intensity on irisin concentration is not well known. Thus, we examine the effect of aerobic training intensity on irisin in streptozotocin (STZ) -induced diabetic Wistar rats.
Material & Methods: Diabetes was induced by intraperitoneal injection of STZ. Animals were randomly divided into four groups (n=8 in each group): control group (CON), diabetes group (D), diabetes and moderate-intensity exercise group (D + ME; running speed was set at 10-17 m.min-1), and diabetes and high-intensity exercise group (D + HE; running speed was set at 17-28 m.min-1). The rats in the exercise groups were made to run on the treadmill for 30 min per one day, 3 times a week, during 8 weeks.
Results: The results indicated that serum irisin concentration was higher in the D + HE group than CON, D and D + ME groups (P<0.05) and no significant differences were observed between CON group and D + ME group.
Conclusions: Our findings suggest that that exercise intensity has an effect on exercise-induced irisin responses.
خلاصه ماشینی:
Effect of aerobic training intensity on irisin in streptozotocin-induced diabetic rats Sahar Heidari1 and Mehrzad Moghadasi2* Received: 8 August 2017 / Accepted: 19 September 2017 (1) MS student in exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran (2) Associate professor in exercise physiology, Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran (*) Associate Professor in Exercise Physiology (PhD) E-mail: mehrzad.
Thus, we examine the effect of aerobic training intensity on irisin in streptozotocin (STZ) -induced diabetic Wistar rats.
By our knowledge, there is no study that was performed to examine the effect of chronic aerobic training intensity on irisin concentration.
moderate-intensity exercise (ME) on irisin in streptozotocin (STZ) -induced diabetic rats.
Irisin plays an important role in energy metabolism (22), glucose tolerance, increasing the expression of GLUT-4 and mitochondrial biogenesis (23) and, further, that irisin can change the browning of adipose tissue in exercise subjects (24).
The results showed that irisin concentration was increased after HE (P receptor γ coactivator 1α or PGC-1α is a molecule involved in the regulation of gene expression that plays a critical role in the maintenance of glucose, lipid, and energy homeostasis (26).
(2012) showed that murine skeletal muscles, upon increased levels of PGC-1α, induce the expression of a protein called fibronectin type III domain containing 5 (FNDC5), which after cleavage is secreted into the blood stream as irisin (2).
Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies.