چکیده:
Introduction: Breast cancer is the most common cancer in
postmenopausal women. Exercise affects breast cancer risk
and outcomes, but little is known about the mechanisms
through which this effect may be mediated. The purpose of
this study was to investigate the effect of 12 weeks aerobic
exercise on plasma leptin and adiponectin in postmenopausal
women with breast cancer.
Material & Methods: Nineteen postmenopausal women with
breast cancer (aged: 55±2.7 years;±SD) volunteered to
participate in this study. The subjects were randomly
assigned to training group (n=11) or control group (n=8).
Subjects in the experimental group performed 12 weeks of an
exercise program which consisted of 25 to 45 minutes of
walking with an intensity of 45-65% of target heart rate,
three times a week.
Results: Body mass and BMI decreased (P<0.05) after 12
weeks exercise training compared to the control group, while
no significant change in body fat percent and WHR were
found. Plasma leptin decreased (P<0.05) and plasma
adiponectin increased (P<0.05) in response to 12 weeks
aerobic exercise training compared to the control group,
while insulin resistance determined by HOMA-IR did not
change in the training group.
Conclusions: In summary, 12 weeks aerobic exercise increase
plasma adiponectin and decrease plasma leptin in
postmenopausal women with breast cancer.
خلاصه ماشینی:
Plasma leptin and adiponectin concentrations in postmenopausal women with breast cancer following aerobic exercise Mehrzad Moghadasi1*, Reza Nouri2, Laleh Karami Bonari3, Shima Gholamalishahi3, Mohadeseh Nematollahzadeh Mahani3 Received: 18 August 2016/ Accepted: 10 November 2016 (1) Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran (2) Department of sport sciences, Kish International Campus, University of Tehran, Kish Island, Iran (3) The General Department of Fars Province Education (*) Correspondence: M.
The purpose of this study was to investigate the effect of 12 weeks aerobic exercise on plasma leptin and adiponectin in postmenopausal women with breast cancer.
Few studies have been carried out to comprehensively analyze the effect of exercise training on adiponectin and leptin levels in women with breast cancer.
Therefore, we evaluated the effect of 12 weeks aerobic exercise on plasma adiponectin and leptin concentrations in postmenopausal women with breast cancer.
Exercise training may reduce the adipose tissue, although it is not well known whether exercise – induced change in adipose tissue, increases plasma adiponectin and decreases plasma leptin concentrations in postmenopausal women with breast cancer or not.
Thus we studied the effect of 12 weeks aerobic exercise on plasma adiponectin and leptin concentrations in postmenopausal women with breast cancer.
There were significant association between plasma adiponectin with body fat percent and WHR after 12 weeks training, thus it seems that exercise-induced changes in body composition may play an important role in increasing plasma adiponectin in postmenopausal women with breast cancer.