چکیده:
Biological marker is a term used in many scientific fields and was introduced as a measurable element or a clinical indicator in the abnormal biological processes, pathological condition, or pharmacological intervention. Science Citation Index Expanded (SCI-E) from database of Web of Science (WoS) was used to extract all publication indexed as a topic of “Biomarkers” during a period of eleven years through 2000-2010. Extracting of data was restricted to the tag of topics (TS = Biomarkers) from advanced search menu. A total number of 37397 records were extracted on 5 May 2013 and went under analysis. In this study the papers originated jointly by multiple authors from different countries were defined as ones for each country. The study showed that the number of publication in the field of biomarkers showed an increase through the period of study. The number of publication in 2010 was greater than 10 times in 2000. More than 98% of publication was in English. The majority of publication (68%) was in the form journal article. Harvard University, sharing 1,128 papers in the field, was the most prolific university among institutes. The USA contributing 33% of world’s profile in the field was the most productive country. Based on the Bradford’s scattering law, the journal of “Cancer Epidemiology Biomarkers Prevention” publishing 3.12% of world’s publication was the most prolific journal among core journals. Analysis of data concluded that oncology was the most interesting subject area of scientists in the field of Biomarkers through the last decade.
خلاصه ماشینی:
Perhaps the traditional definition of biomarkers was used only for the proteins which were measurable in the body fluids; but the progress in the imaging techniques and other diagnostic methods, also has introduced certain conditions such as the structural changes in the human body or brain electroencephalography (EEG) as the biomarker of certain diseases (Beveren and Hoogendijk, 201 I ; Garea, Griese, and Imhof.
, 2011; Mayeux, 2004; Suspiro and Prista, 2011; Vainio, 2001).
Since the biomarkers of a disease are detectable even in the first stages of a pathological condition, these elements attract a lot of interest in the diagnostic processes of specific diseases, in particular, cancer, and the number of publications in this field is growing fast (Au, 2007; Cazzola and Novelli, 2010; Cummings, 2011; Eason and Halloran, 2002; Ganti and Weiss, 2011; Schaaij-Visser, Brakenhoff, Leemans, Heck, and Slijper, 2010).
, 2007; He and Yu, 2012; Lobdell and Mendola, 2005; Mayeux, 2004; Wehrens, Franceschi, Vrhovsek, and Mattivi, 2011).
This study investigated all publication indexed under the topic of Biomarkers in SCI-E and visualized the scientific activity of leading countries in the field through 2000-2010.
Findings Analysis of data obtained from database of Science Citation Index- Expanded (SCI-E) throughout a period of eleven years indicated that the number of publication in the field of Biomarkers has increased steady through the period of study.
Percentage of publication in the field of Biomarkers contributed by G8 countries 2000-2010 The G8 countries altogether contributed 30,249 papers in SCI-E database.
The G8 countries altogether contributed 619c of global publications in the field of Biomarkers in SCI-E database.