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فهرست مقالات

The Effect of Different Intensities in Short- and Long-Term on Nitric Oxide in Obese Men

نویسنده:

(4 صفحه - از 35 تا 38)

خلاصه ماشینی:

"Serum concentration of nitric oxide in high intensity group was significantly higher after four weeks of exercise (p =0/004) and when compared with moderate intensity group (p =0/004). concentration of Nitric oxide (NO) in three times : in fasting blood , after one onset and after four weeks in moderate and high intensity(0<05). They declared that augmented oxidative stress in high intensity cause insignificant change in NO synthesis, although oxidize LDL in which one of the main component of oxidative stress and indicate can cause Dysfunction in NO formation and inactive NO production indirectly was insignificant in their study. It seems that exercise program with high intensity lead to different tension of shear stress on blood vessel wall and create different molecular responds . ‟ Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans". ‟ Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans Role of Endothelium-Dependent Nitric Oxide and Oxidative Stress"."

صفحه: از 35 تا 38
35 Annals of Applied Sport Science , Spring 2015, Volume 3 - Number 9

36 Annals of Applied Sport Science , Spring 2015, Volume 3 - Number 9

37 Annals of Applied Sport Science , Spring 2015, Volume 3 - Number 9

CONCLUSIONS

In this‌ study‌ NO‌ concentration accidentally was higher in moderate intensity group. Significant differences were observed only after‌ four‌ weeks of continues – running training between two groups. This finding in agreement with‌ Arvola‌ et‌ al. (1999),Clerkson et al. (1999), Roberts et al. (2002), Watts et al. (2004), Erich‌ et‌ al. (2008), Sherman et al. (2010). Also this finding is in contrast‌ with‌ the‌ study of Goto et al. (2007, 2008). eNOS activity concomitantly induced by shear stress in‌ order‌ to‌ maintain synthesis of NO in the base line.

Shear stress forces created‌ by‌ gliding of blood flow on the layer of vessel (endothelium). Shear stress probably the most important‌ factor‌ induced NO in the natural condition. During psychical activity shear stress senses‌ by‌ integrins placed in endothelial in basal membrane‌. This‌ mechanism‌ lead to Phosphorylation of PKB and increase‌ eNOS‌ enzyme activity. Goto et al. (2007) indicate significant augment in NO concentration in‌ moderate‌ intensity exercise in healthy participant‌. They‌ declared that‌ augmented‌ oxidative‌ stress in high intensity cause insignificant‌ change‌ in NO synthesis, although oxidize LDL in which one of the main‌ component‌ of oxidative stress and indicate can‌ cause Dysfunction in NO‌ formation‌ and inactive NO production indirectly‌ was‌ insignificant in their study. In our study we asked participant to continue their‌ activity‌ until fatigue threshold in order‌ to‌ decrease‌ the side effect‌ of‌ oxidative stress during Physical‌ Activity‌ also some studies like Ignaro et al. (2007) reported NO augmentation in high intensity‌ in‌ spite of increase oxidative stress and‌ its‌ side effect‌. Survey‌ of‌ Erich et al. (2008‌) Indicate that high intensity training improve endothelial more than continues – running training with moderate intensity‌. It‌ seems that exercise program with high‌ intensity‌ lead‌ to‌ different‌ tension of shear‌ stress‌ on blood vessel wall and create different molecular responds .They suggest that the effect of high‌ intensity‌ exercise‌ mediated by NO production.

REFERENCES

1-IL Williams‌.‟ Obesity‌, atherosclerosis‌ and‌ the‌ vascular‌ endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans". International Journal of Obesity (2002) 26, 754–764.

2-Katie Watts.‟ Exercise Training NOrmalizes Vascular Dysfunction and Improves‌ Central Adiposity in

Obese Adolescents". Journal of the American College of CardiologyVol. (2004) 43, NO. 10:1822 -1827

3-Goto C.‟ Acute moderate-intensity exercise induces vasodilation through an increase in nitric‌ oxide‌ bioavailiability in humans". A m J Hypertens (2007)20(8):825-30.

4-Chikara Goto.‟ Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in

Humans Role of Endothelium-Dependent Nitric Oxide and‌ Oxidative‌ Stress". Circulation. (2008) 2003;

108:530-535.

5-Louis J. Ignarro a,‟ Nutrition, physical activity, and cardiovascular disease: An update". Cardiovascular

Research (2007). 73 : 326–340‌

38 Annals of Applied Sport Science , Spring 2015, Volume 3 - Number 9