چکیده:
Objectives:In this study, we examined the effect of botulinum toxin A (BTA) on chronic allergic rhinitis (CAR). We tested the effects of BTA, applied to an intranasal sponge, on patients who had CAR for a minimum of three years and had been treated unsuccessfully with conventional medications. Method:The study was an interventional case-control single-blind randomized clinical trial. Forty-four male and female CAR patients who were referred to Tehran’s Saee & Pasargad Hospitals, and Saadat-Abaad, Sarv and Karimkhan Clinics in 2012 aged 20-40 years were selected on the basis of inclusion and exclusion criteria. The subjects were randomly assigned to the intervention (n=22) or control group (n=22). The intervention group received BTA (100 IU/ml Dysport), on a 5cm nasal sponge retained in each nasal cavity for 30 minutes. The control group received normal saline. The groups were evaluated by the same examiner. Pre- and post-tests (1, 3, 6, and 12 weeks) were performed according to the authors’ pre-designed checklist, the validity and reliability of which was previously established. The symptoms scored from none (0) to severe (10) at the test points. The statistical analysis was conducted with SPSS-19, with a significance level of 0.05. Results:Based on ANOVA, there was a significant difference (P<0.05) in symptomatic relief between the intervention and control groups. No marked adverse effects were observed during the study. Discussion:An intranasal 5cm sponge impregnated with 100 IU/ml BTA, retained in each nasal cavity for 30 minutes, may alleviate CAR symptoms with no significant adverse effects.
خلاصه ماشینی:
Tehran University of Medical Sciences, Tehran, Iran Objectives: In this study, we examined the effect of botulinum toxin A (BTA) on chronic allergic rhinitis (CAR).
We tested the effects of BTA, applied to an intranasal sponge, on patients who had CAR for a minimum of three years and had been treated unsuccessfully with conventional medications.
Discussion: An intranasal 5cm sponge impregnated with 100 IU/ml BTA, retained in each nasal cavity for30 minutes, may alleviate CAR symptoms with no significant adverse effects.
Keywords: Botulinum Toxin-A, disease rehabilitations, chronic allergic rhinitis, intranasal sponge, conventional medications, unsuccessful treatments, Botox, Dysport, Antihistamine, Corticosteroids, Intranasal injection Submitted: 12 June 2013 Accepted: 17 Oct. 2013 Introduction Chronic allergic rhinitis (CAR) is an uncomfortable malady that affects many people around the world (1, 2).
In the present study, we investigated the effects of botulinum toxin A (BTA) on CAR, the extent of these effects, and any undesirable adverse events that might exacerbate the existing symptoms in these patients.
However, after the inclusion criteria were considered (age 20-40 years; sex distribution; CAR suffered for a minimum of three years; previous failure of conventional medication) and the exclusion criteria were applied to the initial sample (no informed consent; age below 20 or above 40 years; having other major systemic illness; history of oronasal surgery; having other extranasal allergic manifestations such as asthma; history of allergy to BTA) as shown in Table (1), 44 patients were selected (22 men and 22 women, age 20-40 years).