خلاصة:
Introduction: In recent studies, balance and postural instability have been reported as a common motor disorder in Parkinson's patients, which leads to frequent falls, decreased quality of life, and mortality in these patients. On the other hand, evidence has shown that training is effective in treating motor and cognitive symptoms of neurodegenerative patients.Methods: For this purpose, 24 male Wistar rats were randomly divided into three groups of eight rats including Healthy Control, Parkinson’s Control, and Parkinson’s Training. The animals in the training group were placed on a treadmill for four weeks. At the end of the course, motor disorders (balance and motor behavior) were evaluated using Rotarod and Open-Field tests, and biochemical factors were assessed by ELISA method. Data analysis was done using one-way ANOVA and Tukey's post hoc test at a significant level of PResults: The results showed that although the Parkinson's group without training was significantly lower in terms of motor performance than the other groups (PPPPPConclusion: In general, the findings of this study showed that moderate-intensity aerobic training can reduce the biochemical and motor disorders induced by 6-hydroxydopamine injections in rats’ models of Parkinson's disease.
ملخص الجهاز:
The Effect of Moderate-Intensity Aerobic Exercise on Balance, Motor Behavior, Serotonin, and Tyrosine Hydroxylase Enzyme in an Animal Model of Parkinson's Disease Sara Soori 1 , Fazlollah Bagherzadeh 2, Rasul Hemayat Talab 3, Mahmoud Sheikh 4 4 1.
ir Article Information Abstract Introduction: Recent studies have reported balance and postural instability as a common motor disorder in patients with Parkinson's disease, leading to frequent falls, reduced quality of life, and mortality in these patients.
Investigating the effect of moderate-intensity aerobic exercise on balance, motor behavior, serotonin, and tyrosine hydroxylase enzyme in an animal model of Parkinson's disease.
Also, the positive effect of exercise on improving motor symptoms of Parkinson's disease, including performing daily activities, improving balance and walking, has been shown in numerous studies (Rafiei et al.
Therefore, in the present study, the effect of four weeks of moderate-intensity aerobic exercise on balance, motor behavior, and biochemical factors (serotonin and tyrosine hydroxylase enzyme) was investigated in rat experimental models of Parkinson's disease.
This research investigated the effect of moderate-intensity aerobic exercise on motor and biochemical symptoms in rat models of Parkinson's disease.
In this study, unilateral injection of 6-hydroxydopamine toxin into the MFB region was used to create an animal model of Parkinson's disease, and motor disorders such as balance and postural instability were assessed using rotarod and open field tests.
Regarding the effect of exercise on tyrosine hydroxylase levels, the results of the present study showed that four weeks of moderate-intensity aerobic exercise significantly increased TH levels in the exercise group rats.
Effects of Voluntary Exercise on Motor Function in Parkinson's disease Model of Rats.
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