خلاصة:
The aim of this study was to investigate the effect of two types of zinc diets during pregnancy and lactation of female mice on the learning, memory, and motor performance of their offspring. Zinc deficiency and zinc supplementation during pregnancy and lactation of the mother may affect the memory, learning, and motor performance of their offspring. The statistical population of this study was albino-Wistar strain female rats purchased from the Pasteur Institute of Iran. After the mating stage, 12 pregnant mothers were selected and divided into 3 groups and consumed the desired diet in the last week of pregnancy and throughout lactation. The first group was the control group, which used standard food; the second group was the zinc supplement group, to which 10 ppm zinc supplement was added to their water; and the third group was the zinc deficiency group, which used food lacking zinc. After applying the independent variable, 12 male mice were considered as a statistical sample for each group, who underwent memory and learning testing through the Morris water maze at 56 days of age, and their motor performance was measured by an activity measurement device (Open Field) at 66 days of age. One-way ANOVA, Tukey's post-hoc test, and repeated measures ANOVA were used for data analysis. The findings of this study showed that zinc deficiency in the last week of pregnancy and lactation causes impairment of learning, memory, and weakness in motor performance. In addition, zinc supplementation improved learning and memory, but had no significant effect on the motor performance of infants.
ملخص الجهاز:
After applying the independent variable, 12 male mouse heads were considered as a statistical sample for each group, who underwent a memory and learning test via the Morris water maze at 56 days of age, and their motor performance was measured using an activity measurement device (dleiF nepO) at 66 days of age.
The results of the two experiments showed that this diet causes a delay in memory development, but in another study, these researchers observed no significant difference in the performance of a motor task in two groups of mice aged 33 days and 4/5 months who had severe zinc deficiency, and this lack of difference was even observed in measuring memory in the (T-shaped) maze311.
Examining the Comparison of Memory and Learning Between Groups The results obtained over the three days of the acquisition stage show that the average time required (Figure 2a) and the average distance traveled (Figure 2b) to reach the hidden platform increased significantly in the zinc deficiency group compared to the control group (P < 0.
Evaluation of Learning and Memory Trend As can be seen, the elapsed time (Figure 3 A) and the distance traveled (Figure 3 B) to reach the hidden platform on the days of the training phase and the recall day decreased significantly compared to the first day in the control and zinc supplement groups, and the percentage of entry into the target quadrant (Figure 3 C) increased significantly in these two groups (P < 0.
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