Abstract:
Introduction: Autophagy is an anti-aging process and is very essential in heart health. The aim of the present study was to compare the effect of two models of high-intensity and moderate-intensity intermittent exercise on sirtuine genes and antioxidant defense factors in the heart muscle of elderly rats. Methods: 24 male Wistar rats with an average weight of 350 ± 50 grams were randomly divided into control, moderate intensity continuous training (MICT) and high intensity interval training (HIIT) groups and underwent training for 8 weeks. Expression of Sirt1, Sirt3 genes was measured using real time-PCR technique and measurement of SOD and GPX concentration by optical absorption. To compare the groups, one-way analysis of variance was used at the alpha level of 0.05.Results: The expression level of Sirt1 and Sirt3 genes in HIIT and MICT groups was significant compared to the control group (pConclusion: Results showed that both types of exercise moderated the expression of Sirt1 and Sirt3 genes compared to the non-exercise group. which probably activates the antiaging pathway of sirtuins in aging mice. Also, the concentration of antioxidant factors increased due to exercise, especially HIIT
Machine summary:
Comparison of the Effect of Interval and Continuous Training on Sirtuin Genes and Antioxidant Defense Factors in the Heart Muscle of Aged Rats Sarah Almasi Ghal'eh 1 , Mandana Gholami 2 , Behzad Bazgir3 , Hossein Abed Natanzari 4 1.
The aim of the present study was to compare the effect of two exercise models, high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), on sirtuin genes and antioxidant defense factors in the heart muscle of aged rats.
Methods: 24 male aged Wistar rats with an average weight of 350±50 grams were randomly divided into control, moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT) groups and trained for 8 weeks.
Therefore, this research seeks to answer the questions of whether there is a difference between the effect of two models of severe interval exercise and moderate-intensity continuous exercise on proteins related to the autophagy pathway, including sirtuins, and serum levels of antioxidant defense factors in elderly rats?
Research Findings The findings of the present study showed that the gene expression levels of Sirt1 in the HIIT and MICT groups were significant compared to the control group.
*P≥0/05, *0/0001, P≥ 0/001* ***P≥ , ***P≥ 0/0001* Discussion and Conclusion In the present study, two models of high-intensity interval exercise and moderate-intensity continuous exercise were compared on sirtuin genes and antioxidant factors in the heart muscle of aged rats.
's (2019) research investigating the cardioprotective effects of moderate-intensity exercise and long-distance exercise through the sirtuin pathway showed that exercise increased Sirt13 levels, reducing apoptosis and oxidative damage in mice [16].
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