چکیده:
Inflammation and pain induced by delayed onset muscle soreness (DOMS) can be induced by eccentric exercise or an unaccustomed activity. The condition can causes problems in exercising and for athletes. The purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. Evaluations were made for total antioxidant Capacity (TAC), muscle damage markers, and DOMS induced pain. Ten healthy young males (age, 25.0 ± 1.6 years; height, 178.9 ± 4.1 cm; body mass, 81.1 ± 6.8 kg; fat%, 14.2 ± 2.1) completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg) and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin (CU) or placebo (P) was taken at the prescribed dose immediately after eccentric squat exercises; administrations were separated by a 14-day washout period. Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a) limb pain (1–10 cm visual analogue scale; VAS), (b) total antioxidant capacity (TAC) (c) serum markers of muscle damage and inflammation. Measurements taken after exercise showed significantly reduced levels of pain, creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in C group compared with group P group (P<0.05). TAC remained significantly high in group C after exercise compared with levels in group P (P<0.05). The findings of this study suggest that a 150mg dose of curcumin may have antioxidant, anti-inflammatory and analgesic effects on DOMS.
خلاصه ماشینی:
"The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS) 1Babak Nakhostin-Roohi*, 2Arash Nasirvand Moradlou, 2Sahar Mahmoodi Hamidabad, 3Babak Ghanivand 1Department of Sport Sciences, Faculty of Humanities, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
1) completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg) and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise.
Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a) limb pain (1–10 cm visual analogue scale; VAS), (b) total antioxidant capacity (TAC) (c) serum markers of muscle damage and inflammation.
The study was designed as a double-blind randomized-controlled crossover trial to compare the effects of taking oral curcumin to those placebo on against evaluation markers of DOMS immediately after a bout of unaccustomed squat exercises.
DISCUSSION To the best of our knowledge, the present study was the first to examine the effects of 150mg curcumin supplement on antioxidant capacity and muscle damage markers after intensive eccentric exercise in humans.
The main findings in this study were as follows: (1) curcumin supplement maintained TAC high, 24 and 48h after exercise (2) It enabled attenuation of CK, LDH, ALT, AST, and experience of pain related to DOMS.
CONCLUSION The results of this study demonstrate that acute curcumin supplement after intensive eccentric exercise can not only keep antioxidant capacity responses high, but also serve to decrease muscle damage and pain in humans."