چکیده:
Diabetes mellitus is one of the most common diseases affecting the endocrine system. It has
been estimated that the prevalence of diabetes mellitus will be increasing in the human
population. It is a metabolic disease characterized by chronic escalation of blood glucose
and disrupted metabolism in carbohydrates, fats and proteins.
This was an experimental study conducted on 40 male Wistar rats. Diabetes was induced in
the animals through Streptozotocin (STZ). After three days, blood glucose levels were
measured. The rats were diagnosed with diabetes when blood glucose was more than 250.
The data were analyzed through SPSS 21. Moreover, the independent t-test was used to
examine the relationship between variables.
Results of statistical analysis in relation to body weight of rats showed that there was a
significant relationship between all groups at P<0.05 except for diabetic group and diabetic
group by Mentha spicata Butanol extract as well as diabetic group by Mentha spicata
butanol extract and diabetic groups by Mentha spicata butanol extract and zinc oxide
nanoparticles. Concerning the glucose levels, the statistical analysis indicated that there was
a significant relationship between all groups at P<0.05.
When applied as a supplement, zinc oxide nanoparticles and Mentha spicata butanol
extract can have anti-diabetic properties, curtailing blood glucose, revealing that
nanoparticles can be used in the future as a treatment for diabetes.
خلاصه ماشینی:
Supplemental Effect of Zinc Oxide Nanoparticles and Mentha spicata butanol Extract on Blood Glucose of Diabetic Wistar Rats Maryam Rakebizadeh1, Mahshid Zahedizadeh1, Yadolah Edalat Panah1* Department of Biology, Islamic Azad University Dehdasht, Dehdasht, Iran.
When applied as a supplement, zinc oxide nanoparticles and Mentha spicata butanol extract can have anti-diabetic properties, curtailing blood glucose, revealing that nanoparticles can be used in the future as a treatment for diabetes.
Keyword: diabetes mellitus, zinc oxide nanoparticles, Mentha spicata ferulacea, glucose, rats * Corresponding author: Yadolah Edalatpanah email:edalatpanah1367@gmail.
The aim of this study was to evaluate the supplemental effect of zinc oxide nanoparticles with Mentha spicata extract on blood glucose levels in diabetic Wistar rats.
5- Streptozotocin-induced diabetic rats received zinc oxide nanoparticles and Mentha spicata butanol extract as a supplement [12].
In the diabetic group with Mentha spicata butanol extract, the results showed that the pre-test mean weight of 260.
Moreover, the Mentha spicata butanol extract was more successful than zinc oxide nanoparticles in reducing the weight of rats.
As for the Mentha spicata butanol extract diabetic group, the results indicated that the pre-test mean weight of 260.
In the diabetic group with Mentha spicata butanol extract, the results showed that the pre-test glucose of 101 increased to 149.
Moreover, the Mentha spicata butanol extract was less successful than zinc oxide nanoparticles in reducing the glucose level of rats.
As for the Mentha spicata butanol extract diabetic group, the results indicated that the pre-test glucose of 96.