Abstract:
Purpose: Hypertension is a major public health problem worldwide and is the most common cardiovascular disease (CVD) risk factor. The present study was designed to investigate the protective effects of regular aerobic training on inflammatory and toxicity markers in right ventricle tissue of male wistar rats exposed to chronic nitro-L-arginine-methyl ester(L-NAME)-induced hypertension.Material and Methods: Thirty two adult, male, Wistar rats were randomly classified into 4 groups; aerobictraining, L-NAME, saline, and baseline groups. Hypertension was induced by administration of L-NAME (10 mg/kg) 6 sessions a week and for 8 weeks. Aerobic training was performed between 25 to 64 minutes and at the speed of 15 to 22 m/min, 5 sessions a week and for 8 weeks.Results: Chronically administration of L-NAME caused a significant increase in angiotensin converting enzyme (ACE), interleukin 6 (IL-6) levels, and a significant decrease in superoxide dismutase (SOD) and nitric oxide (NO) levels, as compared to saline and baseline groups. In contrast, 8 weeks of aerobic training caused a significant increase in SOD, and NO and a significant decrease in IL-6 and protein carbonyl (PC), as compared to L-NAME and saline groups.Discussion and Conclusion: These findings suggest that aerobic training could have a protective effect against inflammation and toxicity caused by hypertension the in right ventricle tissue through up-regulating antioxidant systems and down-regulating the inflammatory and vasoconstrictor factors in hypertensive rats.
Machine summary:
"The present study was designed to investigate the protective effects of regular aerobic training on inflammatory and toxicity markers in right ventricle tissue of male wistar rats exposed to chronic nitro-L-arginine-methyl ester(L-NAME)-induced hypertension.
Results: Chronically administration of L-NAME caused a significant increase in angiotensin converting enzyme (ACE), interleukin 6 (IL-6) levels, and a significant decrease in superoxide dismutase (SOD) and nitric oxide (NO) levels, as compared to saline and baseline groups.
Although, there is a partial list of proposed mechanisms for exercise-induced protection, much controversy exists concerning the effects of aerobic training on the inflammation, toxicity and antioxidant defense systems of the right ventricle tissue, particularly during chronic Nitro-L- arginine-methyl ester (L-NAME)-induced hypertension.
Thus, the purpose of the present study was to determine the protective effects of 8 weeks of aerobic training on the inflammatory marker (interleukin 6, [IL-6]), vascular dysfunction (nitric oxide [NO] and angiotensin-converting enzyme [ACE]) and oxidative/antioxidant (superoxide dismutase [SOD] and protein carbonyl [PC]) markers of right ventricle tissue in the rats exposed to chronic L- NAME-induced hypertension.
Discussion and Conclusion The present study investigated the effects of an 8-week aerobic training on interleukin 6 (IL-6), nitric oxide (NO), angiotensin-converting enzyme (ACE), superoxide dismutase (SOD) and protein carbonyl (PC) parameters of right ventricle tissue in male rats with chronic exposure to N(ω)-nitro-L- arginine methyl ester (L-NAME)-induced hypertension.
In addition, this study, for the first time, showed that treatment with regular aerobic exercise provided significant protection against L- NAME-induced toxicity in the right ventricle tissue through up-regulating antioxidant systems and down-regulating the inflammatory and vasoconstrictor factors in hypertensive rats."