نویسنده: Shoja Shafti، Saeed؛
September 2004 - Number 2 (11 صفحه - از 15 تا 25)
Negative symptoms in schizophrenia are among the important barriers against psychosocial rehabilitation of such patients. Adjunctive drugs can be used for reducing the severity of these symptoms. In this research we studied the efficacy of Clomipramine, Alprazolam, Citalopram, Bromocriptine, Fluoxetine, Nortriptyline, Maprotiline and Fluvoxamine, in this regard. After a primary prevalence survey regarding Negative symptoms, 170 schizophrenic patients were divided into three different groups, and then the aforesaid adjuvant drugs were examined in three double-blind clinical controlled trials. Estimation of negative symptoms by "SANS" were done at the beginning of each trial for the first time and then three weeks later, after prescription of drugs in lower dosage and finally at the end of sixth week, means three weeks after doubling the dosages. The data were analyzed by z and chi-square (X2test) formula. Clomipramine, Alprazolam, Citalopram, Nortriptyline and Maprotiline could reduce the severity of negative symptoms. Their effectiveness in comparing with placebo was statistically remarkable. No important side effect or worsening of positive symptoms was seen in our samples during aforesaid trials. Conservative usage of adjuvant drugs can be an advantageous means for making rehabilitative programs more efficacious than before.خلاصه ماشینی:
"After a primary prevalence survey regard- ing Negative symptoms, 170 schizophrenic patients were divided into three different groups, and then the aforesaid adjuvant drugs were examined in three double-blind clinical controlled trials. Group A ( n = 40 ) for a Clinical Controlled Trial ( CCT ) regarding the effectiveness of Clomipramine , Alprazolam , and Citalopram on reduc- ing the severity of negative symptoms , Groups B ( n = 100 ) with a similar approach with respect to the moderat- ing effect of Bromocriptine , Fluoxetine and Nortriptyline , and finally group C ( n = 30 ) regarding similar effects of Fluvoxamine and Maprotiline. According to the resulted data , Citalopram ( p < 0/001 ) , Alprazolam (p<0/01) and Clomipramine (p< 0/01) were more effective than placebo in reducing the severity of negative symp- toms. 5% (n=15) , and 8% ( n=20 ) of patients in subgroups showed 20% reduction in the severity of some of their negative symptoms under the influ- ence of placebo , Bromocriptine , Fluoxetine and Nortriptyline respectively . / Table 6 - Improvement of Negative symptoms by adjunctive drugs in schizophrenic patients / Table 7 - Characteristics of improved Negative symptoms in each subgroup / Table 8 - Number of improved Negative symptoms in each subgroup In comparing with placebo , Nortriptyline was the most effective ( P<0."
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