چکیده:
Introduction: Visfatin is a newly discovered adipokine. Previous studies showed a direct relationship between plasma visfatin levels and type 2 diabetes mellitus (T2DM). The current study was conducted to investigate the effect of aerobic exercise on plasma visfatin in type 2 diabetic men treated with metformin.Material and Methods: Thirty-six men with type 2 diabetes who consumed metformin (age 46/08 ± 3/08 years, BMI 30/1± 2/32 kg/m2, mean ± SD) volunteered to participate in this study. Subjects were randomly assigned in 2 groups. 18 subjects were in the aerobic exercise group (3 days per week, 35 to 50 minutes perday, 40-55% heart rate reserve) and 18 subjects in the control group. Fasting Plasma visfatin, insulin and glucose concentrations were measured before and after 8 weeks exercise in patients with T2DM and data was analyzed using Repeated Measures (ANOVA) at a Significance level of (P<0.05).Results: The results showed that plasma visfatin levels, insulin, glucose, BMI, WHR and body fatpercentage significantly decreased in aerobic exercise group compared with control group (p<0.05). The peak rate of oxygen consumption (vo2peak) significantly increased in aerobic exercise group compared to control group (p<0.05).Discussion and Conclusion: The present study showed decrease of plasma visfatin induced by aerobic exercise is most likely the result of improving glycemic control in patients with T2DM treated with metformin.
خلاصه ماشینی:
"Results: The results showed that plasma visfatin levels, insulin, glucose, BMI, WHR and body fatpercentage significantly decreased in aerobic exercise group compared with control group (p<0.
Discussion and Conclusion: The present study showed decrease of plasma visfatin induced by aerobic exercise is most likely the result of improving glycemic control in patients with T2DM treated with metformin.
Brema et al reported that 3 months of aerobic exercise, 4 sessions per week with 75% VO2peak, causes significant decrease in the levels of plasma visfatin in obese 30-15 year old patients with newly diagnoses T2DM [9].
In this regard, it has been reported that 12 week exercise training including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week, causes significant reduction of fasting plasma visfatin levels associated with reduced fasting glucose and insulin levels, weight, WHR and percentage of body fat in 48 non-diabetic women aged 50 to 55 who were overweight or obese [23].
In this regard, Haider et al it has been reported that aerobic exercise decreased the plasma visfatin levels associated with the decrease of WHR after 2 and 4 months in patients with type 1 diabetes [27].
In this study, it seems that another of the reasons for decreased plasma visfatin is the reduction of the body fat percentage and WHR induced by aerobic exercise in patients with T2DM.
In conclustion, this study shows the decrease of plasma visfatin levels induced by aerobic exercise associated with the decrease in fasting glucose and insulin levels, percentage body fat and WHR."